Eurodurg Meeting 2001
"Integrating drug utilization studies in wider Europe"

7-9 June, 2001, Prague, Czech Republic
page # 112, abstr. B2

Antimicrobial consumption in polyvalent intensive care unit

Bedenkov A.V., Andreeva A.S., Galkin D.V., Smaznov R.S.

Institute of Antimicrobial Chemotherapy, State Medical Academy, Smolensk, Russia

OBJECTIVES

To determine the patterns of antimicrobial consumption in polyvalent intensive care unit (ICU) (University Teaching Hospital, Smolensk, Russia).

METHODS

Data on the use of antimicrobial agents in a polyvalent ICU of the 1,350-beds and 30-wards Smolensk University Teaching hospital in 1997 and 1999 were collected from ICU records. The use of antibiotics was expressed as the number of defined daily doses (DDD) per 100 bed-days (b-d).

RESULTS

The most amount of antimicrobials were utilized in 1997 with 214.43 DDDs/100 bed-days in comparison to 162.95 DDDs/100 b-d in 1999. The consumption of penicillins decreased from 118.6 DDDs/100 b-d in 1997 to 98.23 DDDs/100 b-d in 1999. A decrease in penicillins utilization was due to penicillin G (from 31.4 to 23.8 DDDs/100 b-d), ampicillin (from 51.9 to 40.8 DDDs/100 b-d) ampicillin/sulbactam (from 10.9 to 0.16 DDDs/100 b-d) and amoxicillin/clavulanate (from 1.7 to 0 DDDs/100 b-d) mostly. Increase in consumption notified for oxacillin (from 22.2. to 33.47 DDDs/100 b-d) only. The consumption of cephalosporins decreased from 20.44 DDDs/100 b-d in 1997 to 11.4 DDDs/100 b-d in 1999, owing to cephalothin (from 4.5 to 0 DDDs/100 b-d), cefotaxime (from 15.4 to 5.3 DDDs/100 b-d), ceftazidime (from 0.19 to 0 DDDs/100 b-d), cefpirome (from 0.3 to 0 DDDs/100 b-d). The consumption increased for cefazolin (from 0 to 5.2 DDDs/100 b-d) and cefuroxime (from 0 to 0.86) only. The consumption of aminoglycosides decreased from 48.9 DDDs/100 b-d to 34.0 DDDs/100 b-d. Of an interest among individual drugs is the decreased gentamicin (from 46.9 to 27.9 DDDs/100 b-d) and increased amikacin (from 0 to 3.5 DDDs/100 b-d) consumption. Among other groups of antimicrobials was evident a decrease in imipenem (from 0.8 to 0.46 DDDs/100 b-d) and ciprofloxacin (5.1 to 1.4 DDDs/100 b-d) consumption.

CONCLUSION

The study has shown that decrease in consumption of antimicrobial is due to all groups of antibiotics, which may be explained by lack of financing. The decrease in consumption of penicillin G, ampicillin and gentamicin is mainly due to well-known high level of antibiotic resistance.